JACKSONVILLE – Each week during the 2023 season, Jaguars "experts" – Tony Boselli, Frank Frangie, Jeff Lageman, Brent Martineau, John Oehser, Brian Sexton, J.P. Shadrick and Kainani Stevens – will analyze the following day's Jaguars matchup.

Up this week:

The San Francisco 49ers at EverBank Stadium in Jacksonville.

Tony Boselli, Jaguars Analyst and Former Jaguars Left Tackle

• The Jaguars will win if:They stop the run on defense, making the 49ers one dimensional so the rely on the drop-back pass. On offense, the Jaguars must match the physicality of the 49ers' defense and run the ball. Controlling the line of scrimmage is key.
• The 49ers will win if: They keep the Jaguars' offense off-schedule and behind the chains, which will give Joey Bosa, Chase Young and the rest of their defensive line an opportunity to have a big day harassing Trevor Lawrence.  Offensively, if the 49ers get the ground game going with Christian McCaffery, it sets up their play-action pass and this is when they are at their best. 
• As Boselli sees it:This is going to be a physical game, and go down to the wire. I think the Jags will continue to play great run defense, and offensively will run the ball.  Based on this, the Jaguars win, 24-21.

Frank Frangie, Radio Voice of the Jaguars

• The Jaguars will win if: They play one of their better games against a good and angry 49ers team. San Francisco has lost three consecutive games and will be ready to play. The Jaguars must protect; they must block Nick Bosa – and now Chase Young. And they must contain McCaffrey and wide receiver Deebo Samuel, who should return this week. There are weapons on both sides of the ball for the 49ers. Don't let the pass-rushers on defense on those great weapons on offense take over the game.
• The 49ers will win: If they can stuff Etienne and make the Jags one-dimensional, and then harass Lawrence. They want to make Lawrence pass on their terms, not his. This is a far better Jags team than the ones the 49ers beat in recent seasons. The Jags are one of the more complete teams in the NFL.
• As Frangie sees it: The days of the Jags being overmatched are over. They will be in every game and win many. The 49ers are very good, better than the last three games indicate. This is one of the best games of the year. If the Jags play their game, stay on schedule and avoid the big plays from the Niners' big playmakers, they will win the game.

Jeff Lageman, Jaguars Analyst and Former Jaguars Defensive End

• The Jaguars will win if: They win the turnover battle. The 49ers have lost three consecutive games and have lost the turnover battle during that span. The Jaguars must continue their productivity on the defensive side in getting takeaways and do a better job of protecting the football on offense.
• The 49ers will win if: They get running back Christian McCaffrey rolling on the ground, thus keeping a Jaguars defense off balance with play action. Purdy has been struggling a bit and nothing better for a young quarterback than to have an effective running game to ease the pressure.
• As Lageman sees it: This is arguably the best matchup in the NFL this week and many eyeballs will be on this game. The Jaguars have been on a roll with five consecutive wins, and this may be the stiffest challenge yet. Lawrence must continue his level of play and maybe even take it to another level along with his offensive line against a formidable defensive front. This should be a fantastic environment for a must-see game. Get your popcorn ready!

Brent Martineau, Action Sports Jax Sports Director

• The Jaguars will win if: They protect Lawrence. I think you can go a lot of ways with this game, but I think it's time for this Jaguars offense to take off. The Jaguars will face a 49er front that has a lot of name recognition, but their production hasn't lived up to their resumes so far this season. If the Jaguars can keep that trend going, Lawrence will have time and I think this could be a really good Jaguars offensive performance.
• The 49ers will win if: They win the turnover battle. The Jaguars have been getting away with turnovers on the road and still winning. That needs to stop. If San Francisco can force mistake and hold onto the football, that's the formula for a 49ers cross-country win.
• As Martineau sees it: The 49ers are desperate and dangerous after losing three consecutive games. The Jaguars are businesslike. The nation might think the 49ers are the better team, but I'm not sure why that's the case. I like the Jaguars at home to win, 30-19.

John Oehser, jaguars.com Senior Writer

• The Jaguars will win if: They hold the 49ers under 100 yards rushing and get at least seven points off turnovers. The Jaguars have been strong in these areas all season. The areas form the team's identity. If the Jaguars play to their identity, they're good enough to beat a team as good as the 49ers.
• The 49ers will win if: Purdy plays mistake-free and they harass Lawrence into mistakes. The 49ers have a pass rush capable of wrecking games, but the thought here is the key is Purdy. He has thrown five interceptions during the 49ers' three-game losing streak.
• As Oehser sees it: The oddsmakers are favoring the 49ers. Perhaps that's because the 49ers are desperate for a victory to snap their three-game losing streak. The Jaguars have won five consecutive games for a reason, though. They're good enough to win Sunday without playing spectacularly. The thought here is they will do just that.

Brian Sexton, jaguars.com Senior Correspondent

• The Jaguars will win if: They win the turnover battle. The Jaguars have turned the ball over eight times during their five-game winning streak. That formula isn't sustainable, especially against a defense as good as San Francisco's. Mistakes that didn't cost them against the New Orleans Saints and Pittsburgh Steelers will against the 49ers. They must protect the football Sunday.
• The 49ers will win if: They can keep Jaguars quarterback Trevor Lawrence from getting comfortable in the pocket. San Francisco already had $202 million guaranteed in three of four starters then traded for defensive end Chase Young last week. They put a ton of pressure on quarterbacks and force quick decisions. If they can make Lawrence make more mistakes than their own quarterback, Brock Purdy – who has turned the ball over six times in three consecutive losses – they will win.
• As Sexton sees it: This will be a huge test for both the Jaguars offense and defense. San Francisco has elite weapons on both sides of the ball and a head coach to match. San Francisco Head Coach Kyle Shanahan is outstanding. Jaguars Head Doug Pederson is at least his equal, which makes this a great matchup. The Jaguars have been playing well. Can they play great coming off the bye against a desperate 49ers squad? If they can, they'll win their sixth consecutive game.

J.P. Shadrick, jaguars.com Senior Reporter

• The Jaguars will win if: They can slow the 49ers offense and win the turnover battle. The 49ers are poised to have some offensive weapons return this week. Also, the Jaguars left at the bye week tied for the league-high total of fumbles lost, while they're still tied for the league-high takeaway total on defense. If they win the turnover battle and cash in better in the red zone, this Jags team can compete with any in the NFL.
• The 49ers will win if: They stop the Jaguars running game and focus their pressure on Lawrence in unfavorable down-and-distance situations. The 49ers are stout against the run, so staying on the field is not easy against them. The longer the Jags can stay on the field on offense, the better it is to tire out the 49ers D. Also, if McCaffrey gets going for the 49ers offense, it could be a long day.
• As Shadrick sees it: We have arrived at the business half of the 2023 season, and what better way to find out if this Jaguars team has the physicality to hang with the big boys than with a matchup against the 49ers. This will take a full 60-minute fight, and the Jaguars need to hit this team early and set the tone. Three of the next four are at home, and the Jaguars can set the table for a run with a win.

Kainani Stevens, Jaguars Team Reporter

• The Jaguars will win if: Lawrence can feel comfortable in the pocket. Bosa and Young are not going to make things easy for Jacksonville's offensive line. The return of left guard Walker Little gives them a boost and should help keep No. 16 upright.
• The 49ers will win if: McCaffrey runs wild. The Jaguars' defense has been impressive stopping the run, but McCaffrey can burn you in a myriad of ways. Getting behind early against such a dynamic team is not advised.
• As Stevens sees it: I'm going to continue to ride the wave. I think this will be a statement win for the Jags as the defense will feast on Purdy. Jacksonville wins by double digits, 35-21.