JACKSONVILLE – They started slowly and never got faster.

Against this opponent, that was trouble.

Trevor Lawrence was sacked five times, lost a fumble and threw two interceptions. The defense allowed touchdowns to start both halves. All in all, little went right and a lot went wrong for the Jaguars in a 34-3 loss to the San Francisco 49ers in front of 69,271 at EverBank Stadium Sunday afternoon.

"We obviously have to look in the mirror and figure some things out," Jaguars Head Coach Doug Pederson said.

The loss snapped an NFL-high five-game winning streak for the AFC South-leading Jaguars (6-3). The NFC West-leading 49ers (6-3) snapped a three-game losing streak.

"We know the type of team we're capable of being," Jaguars linebacker Foye Oluokun said. "We should have been ready to go from the [bye week the previous week], but the NFL will humble you.

"It's about how you finish the season. Let's finish the right way."

Lawrence, the Jaguars' third-year quarterback, completed 17 of 29 passes for 185 yards and no touchdowns. The Jaguars overall committed four turnovers, with wide receiver Christian Kirk losing a third-quarter fumble.

Lawrence called it "one of the worst games I've played in my career."

"You have to feel the pain and the embarrassment of today," Lawrence said. "I feel that and I take responsibility for that."

Pederson called the loss "a humbling experience."

"Nobody wants to go out and coach that way," Pederson said. "Nobody wants to go out and play that way. Nobody wants to go out and lose that way. Way too much pride, you know?"

The Jaguars' three points were their lowest since a 20-0 loss to the Tennessee Titans in Week 14 of the 2021 season and their fewest at home since a 27-3 loss to the Pittsburgh Steelers in 2020 Week 11. Their four turnovers were a season-high and most since a Week 4 loss at Philadelphia last season.

It was the Jaguars' most one-sided home loss since a 45-15 loss to the Los Angeles Chargers in Week 14 2019 and the worst loss overall since a 50-10 loss to the New England Patriots at New England in Week 17 2021.

"We played terrible, just across the board, including myself," Lawrence said. "That's the reality of it. We're going to watch the tape tomorrow and kind of relive it, which is going to suck, and then we're going to move on."

San Francisco quarterback Brock Purdy capped the 49ers' first drive of the game with a touchdown pass to wide receiver Brandon Aiyuk for an early lead, and Purdy's deep touchdown pass to tight end George Kittle opened the third quarter for a seventeen-point San Francisco lead.

The 49ers led 10-0 after two drives, at which point the Jaguars did not have a first down.

"I thought the team was ready," Pederson said. "We failed to execute on the opening drive defensively and we failed to execute on opening drive offensively.  That's the part that is disappointing because these guys were ready to go.

"To have a lack of execution like we did early in the football game, it just kind of snowballed from there."

Purdy completed 19 of 26 passes for 296 yards and three touchdowns with no interceptions. Kittle caught three passes for 116 yards and a touchdown.

The 49ers outgained the Jaguars 437-221, with wide receiver Deebo Samuel adding a reverse for a touchdown late in the third quarter.

The Jaguars did not force a turnover after entering the game leading the NFL in the category with 18. They are 0-2 this season when not forcing a turnover, and Oluokun registered the team's two sacks.

"That's not the type of football team that we want to be right there, so let's start fighting," Oluokun said. "Let's start working to be better. We have a good opponent coming in next week (the Tennessee Titans of the AFC South). I'm ready to work."

Step by Step:

• The 49ers took control early, forcing a three-and-out on the first Jaguars possession then driving 57 yards on four plays and taking a 7-0 lead when Purdy passed 13 yards to Aiyuk with 11:34 remaining in the first quarter. The Jaguars failed to get a first down on either of their first two possessions, with the 49ers registering sacks on both possessions. Kicker Jake Moody's 39-yard field goal with 4:21 remaining in the first quarter capped the 49ers' second possession and gave them a 10-0 lead.
• The Jaguars' defense stopped the 49ers on back-to-back series following Moody's field goal, with the Jaguars turning in an impressive second-quarter drive to cut the lead to a score. Kicker Brandon McManus' 37-yard field goal with 4:20 remaining in the second quarter made it 10-3, 49ers. The Jaguars drove 80 yards on 14 plays on the series after starting on their one-yard line. Moody's 35-yard field goal on the half's final play pushed the 49ers' lead to 13-3.
• Kittle's 66-yard touchdown on the second play of the third quarter pushed the lead to 20-3, turning a seven-point game into a 17-point lead in 40 seconds. The Jaguars' turnover issues continued later in the quarter, with 49ers cornerback Ambry Thomas recovering a fumble by Kirk at the 49ers' six-yard line. Samuel capped the ensuing drive with a 23-yard run for a 27-3 49ers lead with 1:20 remaining in the third quarter.
• A 22-yard pass from Purdy to fullback Justin Juszczyk gave the 49ers a 34-3 lead with 12:40 remaining in the fourth quarter, a play that came three plays after Lawrence's second interception.

Notable:

• Wide receiver Zay Jones, ruled out on Friday with a knee injury, was the lone starter among five players ruled out for the Jaguars Sunday. Safety Andre Cisco and cornerback Tyson Campbell, questionable on the final injury report of the week Friday with hamstring injuries, were active. The Jaguars' other four inactive players Sunday: Cornerback Montaric Brown, outside linebacker Yasir Abdullah, offensive lineman Cole Van Lanen and defensive tackle Angelo Blackson.

Injury Report:

• Wide receiver/returner Jamal Agnew sustained a first-quarter shoulder injury and did not return.
• Campbell sustained a third-quarter hamstring injury and did not return.